Serveur d'exploration sur le lymphœdème

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PR07A SYSTEM FOR QUANTIFYING LYMPHATIC VESSEL ABNORMALITIES IN LYMPHEDEMA MODELS, AND LOCO‐SYSTEMIC EFFECTS OF PRO‐LYMPHATIC TUMOR GROWTH FACTORS

Identifieur interne : 007536 ( Main/Exploration ); précédent : 007535; suivant : 007537

PR07A SYSTEM FOR QUANTIFYING LYMPHATIC VESSEL ABNORMALITIES IN LYMPHEDEMA MODELS, AND LOCO‐SYSTEMIC EFFECTS OF PRO‐LYMPHATIC TUMOR GROWTH FACTORS

Auteurs : R. Shayan [Australie] ; T. Karnesis [Australie] ; K. Paavonen [Australie] ; M. G. Achen [Australie] ; G. I. Taylor [Australie] ; S. A. Stacker [Australie]

Source :

RBID : ISTEX:1D97550850CA75A55AA23EBD27B4B9B9D1565970

Abstract

Purpose  Lymphatic vessels are critical in interstitial fluid balance, and congenital or acquired derangements lead to accumulation of lymph fluid (lymphedema). Further, when induced by pro‐lymphatic growth factors in tumors, they facilitate lymph node metastasis(1). While histological vessel density is counted on tissue sections, there is no method for quantifying lymphatic morphology and patterning in 3‐D; key elements in fluid dynamics and cellular interactions that underlie lymphatic function and diseases resulting from alterations to them. We have developed a method to quantify important biological and functional parameters in lymphatics, to help distinguish subtle phenotypic differences and patterning defects.

Url:
DOI: 10.1111/j.1445-2197.2007.04127_7.x


Affiliations:


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Le document en format XML

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<div type="abstract">Purpose  Lymphatic vessels are critical in interstitial fluid balance, and congenital or acquired derangements lead to accumulation of lymph fluid (lymphedema). Further, when induced by pro‐lymphatic growth factors in tumors, they facilitate lymph node metastasis(1). While histological vessel density is counted on tissue sections, there is no method for quantifying lymphatic morphology and patterning in 3‐D; key elements in fluid dynamics and cellular interactions that underlie lymphatic function and diseases resulting from alterations to them. We have developed a method to quantify important biological and functional parameters in lymphatics, to help distinguish subtle phenotypic differences and patterning defects.</div>
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