PR07A SYSTEM FOR QUANTIFYING LYMPHATIC VESSEL ABNORMALITIES IN LYMPHEDEMA MODELS, AND LOCO‐SYSTEMIC EFFECTS OF PRO‐LYMPHATIC TUMOR GROWTH FACTORS
Identifieur interne : 007536 ( Main/Exploration ); précédent : 007535; suivant : 007537PR07A SYSTEM FOR QUANTIFYING LYMPHATIC VESSEL ABNORMALITIES IN LYMPHEDEMA MODELS, AND LOCO‐SYSTEMIC EFFECTS OF PRO‐LYMPHATIC TUMOR GROWTH FACTORS
Auteurs : R. Shayan [Australie] ; T. Karnesis [Australie] ; K. Paavonen [Australie] ; M. G. Achen [Australie] ; G. I. Taylor [Australie] ; S. A. Stacker [Australie]Source :
- ANZ Journal of Surgery [ 1445-1433 ] ; 2007-05.
Abstract
Purpose Lymphatic vessels are critical in interstitial fluid balance, and congenital or acquired derangements lead to accumulation of lymph fluid (lymphedema). Further, when induced by pro‐lymphatic growth factors in tumors, they facilitate lymph node metastasis(1). While histological vessel density is counted on tissue sections, there is no method for quantifying lymphatic morphology and patterning in 3‐D; key elements in fluid dynamics and cellular interactions that underlie lymphatic function and diseases resulting from alterations to them. We have developed a method to quantify important biological and functional parameters in lymphatics, to help distinguish subtle phenotypic differences and patterning defects.
Url:
DOI: 10.1111/j.1445-2197.2007.04127_7.x
Affiliations:
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<front><div type="abstract">Purpose Lymphatic vessels are critical in interstitial fluid balance, and congenital or acquired derangements lead to accumulation of lymph fluid (lymphedema). Further, when induced by pro‐lymphatic growth factors in tumors, they facilitate lymph node metastasis(1). While histological vessel density is counted on tissue sections, there is no method for quantifying lymphatic morphology and patterning in 3‐D; key elements in fluid dynamics and cellular interactions that underlie lymphatic function and diseases resulting from alterations to them. We have developed a method to quantify important biological and functional parameters in lymphatics, to help distinguish subtle phenotypic differences and patterning defects.</div>
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